Minimal change nephrotic syndrome and cyclophosphamide.

نویسنده

  • R S Trompeter
چکیده

The term 'minimal change nephrotic syndrome' has become synonymous with the expression 'steroid responsive nephrotic syndrome', the latter term having the merit of focusing on the most important objective characteristic of the condition. Nevertheless, it is somewhat illogical to define this condition by a negative histological feature, which in the majority of cases remains a presumption inferred from the steroid response. It is paradoxical that the major role of immunosuppressive agents in the treatment of the nephrotic syndrome of childhood is in that group with the least convincing evidence of immunopathogenesis-namely, the steroid responders and the patients with minimal change nephrotic syndrome resistant to steroids. Alkylating agents were first used in 1952, and the first report of the use of cyclophosphamide in children occurred more than 20 years ago.'

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منابع مشابه

Minimal change nephrotic syndrome and cyclophosphamide

The term 'minimal change nephrotic syndrome' has become synonymous with the expression 'steroid responsive nephrotic syndrome', the latter term having the merit of focusing on the most important objective characteristic of the condition. Nevertheless, it is somewhat illogical to define this condition by a negative histological feature, which in the majority of cases remains a presumption inferr...

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Minimal change nephrotic syndrome and cyclophosphamide

The term 'minimal change nephrotic syndrome' has become synonymous with the expression 'steroid responsive nephrotic syndrome', the latter term having the merit of focusing on the most important objective characteristic of the condition. Nevertheless, it is somewhat illogical to define this condition by a negative histological feature, which in the majority of cases remains a presumption inferr...

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Minimal change nephrotic syndrome and cyclophosphamide

The term 'minimal change nephrotic syndrome' has become synonymous with the expression 'steroid responsive nephrotic syndrome', the latter term having the merit of focusing on the most important objective characteristic of the condition. Nevertheless, it is somewhat illogical to define this condition by a negative histological feature, which in the majority of cases remains a presumption inferr...

متن کامل

Minimal change nephrotic syndrome and cyclophosphamide

The term 'minimal change nephrotic syndrome' has become synonymous with the expression 'steroid responsive nephrotic syndrome', the latter term having the merit of focusing on the most important objective characteristic of the condition. Nevertheless, it is somewhat illogical to define this condition by a negative histological feature, which in the majority of cases remains a presumption inferr...

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Treatment with Cyclophosphamide for steroid-resistant nephrotic syndrome in children.

The management of patients with steroid-resistant nephrotic syndrome remains difficult. We repport our experience with Cyclophosphamide therapy, in an attempt to compare the results between an oral protocol and two i.v. protocols. The complete and sustained general remission rate was 43.1%, which confirms the efficacy of the treatment, especially for children with minimal change nephrotic syndr...

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عنوان ژورنال:
  • Archives of disease in childhood

دوره 62 2  شماره 

صفحات  -

تاریخ انتشار 1986